Additional file 1 of Mapping the genetic landscape of early-onset Alzheimer’s disease in a cohort of 36 families

Additional file 1: Table S1. List of dementia related genes and loci that were analyzed in the exome sequencing data for each family separately. Table S2. List of variants and genes that were excluded following manual evaluation using the Integrative Genomics Viewer (IGV). Table S3. List of variants (n = 35) included to compute the Polygenic Risk Score (PRS). Table S4. Clinical and genetic findings of all affected individuals (n = 77) and unaffected relatives (n = 4). Table S5. Selection of genes shared by two families with possible connection to dementia based on literature search. Table S6. Total list of candidate genes (n = 37) and variants (n = 78) occurring in ≥2 families selected for replication analysis. Table S7. Replication analysis of candidate genes. Table S8. Replication analysis of candidate variants.