Clinical and laboratory characteristics of mastocytosis patients.

SM, systemic mastocytosis; ISM, indolent SM; SM-AHNMD, SM with associated non-mast cell lineage disease; ASM, aggressive SM; MSC, mast cell sarcoma; M, male; F, female; AST, aspartate aminotransferase; LDH, lactate dehydrogenase. NA, not available.*Includes pruritis, flushing, urticaria, and angioedema.†Includes weight loss, fever, chills, and night sweats.‡Includes headache, dizziness/lightheadedness, syncope/presyncope, hypotension, anaphylaxis, palpitation/tachycardia, bronchoconstriction/wheezing, and peptic ulcer disease.§Weight loss of >10% of normal body weight over a period of 6 months or less.IIPalpable splenomegaly or hepatomegaly.¶Lymphadenopathy on palpation or imaging.ΔThe diagnosis of mast cell sarcoma was made based on a right femoral biopsy (patient 16).∑One patient with ISM had anemia at the time of sampling; the causes of anemia were bacterial endocarditis and renal insufficiency related to a proliferative glomerulonephritis (patient 12 of Table 2).ΠOne patient who fulfilled criteria for SM-AHNMD had a low tryptase level of 10.7 ng/mL which was taken at the time of AML remission (patient 17 of Table 2).