Synthesis And Antimicrobial Evaluation Of Some New N-(2,4 Dichlorobenzyl)- Indolylchalcones From 1h-indolyl-3 phenylpropenones

Abstract:-Series of new 1-{N-(2,4-dichlorobenzyl)indolyl)}-3-phenylpropanones were synthesized. The<br>intermediate 1H-indolyl-3-phenylpropenones were synthesized by the reaction of indole-3-carboxaldehyde with<br>appropriate acetophenone in the presence of piperidine under reflux condition. Thus, the prepared intermediate<br>indolyl chalcones has been subsequently treated with 2,4-dichlorobenzyl chloride in the presence of potassium<br>carbonate and DMF as solvent under reflux condition to afford title compounds in good yield. The structures of<br>intermediate and newly synthesized N-(2,4 dichlorobenzyl)- indolylchalcones were confirmed by physical and<br>spectral analysis. All the N-(2,4 dichlorobenzyl)- indolylchalcones were evaluated for antibacterial and antifungal<br>activities. Selected N-(2,4 dichlorobenzyl)- indolylchalcones showed good to excellent antibacterial and antifungal<br>activities with reference to the well-established standards.