RNA-seq of mosaic Down syndrome hiPSCs derived cardiac cells (differentiation on 8)

NIAID Data Ecosystem2026-05-10 收录

器官细胞基因表达谱

唐氏综合征分子机制

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP399419 数据链接链接失效反馈

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资源简介：

To know gene expression patterns affected by 3 copies of chromosome 21 in cardiac cells Overall design: isogenic pair: Normal hiPSCs- and Trisomy 21 hiPSCs-derived cardiac cells

创建时间：

2025-09-24

Questioned validity of GEDDs in DS

唐氏综合征分子机制

基因表达验证

Recently, in studies examining fibroblasts obtained from the tissues of one set of monozygotic twins (i.e. fetuses derived from the same egg) discordant for trisomy 21 (Down syndrome; DS), Letourneau

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Gene expression profiling of mouse liver cells. Gene expression profiling of mouse liver cells

单细胞转录组学

器官细胞基因表达谱

We generated the individual transcriptomes of 96 liver cells using the Fluidigm C1 platform. In brief, a suspension of cells was prepared from the liver of a 14-week old B6CastF1 (C57Bl/6J mother x CA

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Trisomy of a ‘Down syndrome critical region’ globally amplifies transcription via HMGN1 overexpression [ChIP-Seq]. Trisomy of a ‘Down syndrome critical region’ globally amplifies transcription via HMGN1 overexpression [ChIP-Seq]

唐氏综合征分子机制

精子染色质表观遗传学

Down syndrome (DS, trisomy 21) is associated with developmental abnormalities and increased leukemia risk. To reconcile chromatin alterations with transcriptome changes in cells with trisomy 21, we pe

NIAID Data Ecosystem40

DataSheet1_Overexpression of the Hsa21 Transcription Factor RUNX1 Modulates the Extracellular Matrix in Trisomy 21 Cells.docx

唐氏综合征分子机制

RUNX1调控细胞外基质

Down syndrome is a neurodevelopmental disorder frequently characterized by other developmental defects, such as congenital heart disease. Analysis of gene expression profiles of hearts from trisomic f

NIAID Data Ecosystem70

Trisomy of a ‘Down syndrome critical region’ globally amplifies transcription via HMGN1 overexpression [NALM6 RNA-Seq]. Trisomy of a ‘Down syndrome critical region’ globally amplifies transcription via HMGN1 overexpression [NALM6 RNA-Seq]

唐氏综合征分子机制

白血病转录组

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