2-state HMM parameter estimates for LFA-1.

Maximum likelihood parameter estimates for a 2-state HMM applied to an ensemble of independent LFA-1 single particle tracks, labeled with beads coated with either ICAM-1 or the antibody TS-1/18, under various treatment conditions, as indicated (PMA: phorbol 12-myristate 13-acetate; cyto D: cytochalasin D; lova: lovastatin; cal-I: calpain inhibitor I). See reference [22] for details of treatment conditions and SPT setup. Derived parameters: and are stationary probabilities for the two states, and is a pseudo equilibrium constant. is an effective diffusion coefficient for the 2-state model. values reported here are nearly identical to the maximum likelihood diffusion coefficient for a simple diffusion model, as defined in equation 8. All diffusion coefficients are reported in .