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Circularization of Single-Stranded DNA Donor Template Unleashes the Power of Non-Viral Gene Delivery for HSPCs editing

NIAID Data Ecosystem2026-05-10 收录

非病毒基因递送优化

基因编辑造血干细胞

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP615863 数据链接链接失效反馈

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资源简介：

CITE-seq analysis comparing the edition of HSPCs by a TALEN using either circular single-stranded DNA or AAV6 donor templates.

应用场景：

创建时间：

2025-10-01

基因编辑造血干细胞

p53DNA损伤应答

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem60

Clonal Tracking Uncovers Barriers and Validate New Strategies to Enhance Gene Editing in Human Hematopoietic Stem Cells [RNA-seq]

基因编辑造血干细胞

CRISPR-Cas9HDR优化

By applying a barcoding strategy to clonal tracking of edited cells (BAR-seq), we show that p53 activation triggered by HDR editing significantly shrink the HSPC clonal repertoire in hematochimeric mi

NIAID Data Ecosystem50

Choice of Template Delivery Mitigates the Genotoxic Risk and Adverse Impact of Editing in Human Hematopoietic Stem Cells. Choice of Template Delivery Mitigates the Genotoxic Risk and Adverse Impact of Editing in Human Hematopoietic Stem Cells

基因编辑造血干细胞

基因治疗安全性

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem40

Senescence and inflammation are unintended consequences of CRISPR-Cas9 gene-editing in hematopoietic stem cells [WES]. undefined

基因编辑造血干细胞

基因治疗安全性

Gene editing (GE) in hematopoietic stem and progenitor cells (HSPCs) represents a promising strategy for site-specific gene correction of several inherited diseases. However, its clinical translation

NIAID Data Ecosystem50

Choice of Template Delivery Mitigates the Genotoxic Risk and Adverse Impact of Editing in Human Hematopoietic Stem Cells (Targeted deep sequencing)

基因编辑造血干细胞

基因治疗安全性

Long-range gene editing by homology-directed repair (HDR) in hematopoietic stem/progenitor cells (HSPCs) often relies on viral transduction with recombinant adeno-associated viral vector (AAV) for tem

NIAID Data Ecosystem40

Circularization of Single-Stranded DNA Donor Template Unleashes the Power of Non-Viral Gene Delivery for HSPCs editing

资源简介：

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