Long-term adaptation of S. aureus in CF patients

The lungs of Cystic fibrosis (CF) patients are often colonized and/or infected by Staphylococcus aureus for years, mostly by one predominant clone. For long-term survival in this environment, S. aureus needs to adapt during its interactions with host factors, antibiotics, and other pathogens. Here, we study long-term adaptations of an isogenic pair of S. aureus isolates from a single patient using whole genome sequencing (WGS).