Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor.
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Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor. Descriptor: 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea, Vascular endothelial growth factor receptor 2 Authors: Oguro, Y, Miyamoto, N, Okada, K, Takagi, T, Iwata, H, Awazu, Y, Miki, H, Hori, A, Kamiyama, K, Imanura, S. Deposit date: 2011-08-24 Release date: 2011-11-02 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation. Bioorg.Med.Chem., 18, 2010
创建时间：
2011-08-24
