The CGG KI Mouse Model does not show Learning and Memory Deficits on the Water maze or Motor Deficits on the Rotarod

In this study, CGG KI mice modeling the fragile X premutation were tested on the Morris water maze. There were no group differences among mutant mice and littermate controls during acquisition and the probe trial. Neither were there deficits for motor learning on the accelerating rotarod. Importantly, these same mice shows deficits for fine spatial processing using more sensitive behavioral assays (Hunsaker MR, et al. Progressive spatial processing deficits in a mouse model of the fragile X premutation. Behav Neurosci. 2009 Dec;123(6):1315-24. doi: 10.1037/a0017616. PubMed PMID: 20001115; PubMed Central PMCID: PMC3410547)