Radical-Organometallic Hybrid Reaction System Enabling Couplings between Tertiary-Alkyl Groups and 1‑Alkenyl Groups

Suzuki–Miyaura
couplings of tertiary-alkyl moieties are
accomplished in the presence of a copper catalyst, in which quaternary
carbons possessing various functional groups can be synthesized via
a radical reaction. Mechanistic studies revealed that 1-alkenylcopperI plays an important role in this coupling reaction. We expect
that the radical-organometallic combined process will become one of
the best options for the synthesis of quaternary carbons.