GAMinG script (python) and sequence file (.dat) to prepare files to run molecular dynamics in GROMACS (see ndb.rice.edu for more info regarding how to run the simulations). Two .hic maps and two sampl

NIAID Data Ecosystem50

Oncogene-Mediated Alterations in Chromatin Conformation. Homo sapiens

三维基因组学

癌症表观遗传学

Emerging evidence suggests that chromatin adopts a non-random three-dimensional (3D) topology and that the organization of genes into structural hubs and domains affects their transcriptional status.

NIAID Data Ecosystem20

3D genomics across the tree of life reveals condensin II as a determinant of architecture type

三维基因组学

进化基因组结构

We investigated genome folding across the eukaryotic tree of life. We find four general manifestations of genome organization at chromosome-scale that each emerge and disappear repeatedly over the cou

NIAID Data Ecosystem60

The nuclear matrix associating protein HNRNPU functions as a key regulator of 3D genome architecture [Hi-C]

三维基因组结构

染色质互作

Higher-order chromatin conformation plays critical role in regulating gene expression and biological development, here we show that HNRNPU, a nuclear matrix attachment factor, is a regulator of 3D gen

NIAID Data Ecosystem30

InfoHiC models for cancer Hi-C prediction (NPC, 1Mb window, 40kb resolution)

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