CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628

CryoEM structure of activated CRAF/MEK/14-3-3 complex with NST-628 Descriptor: 14-3-3 protein sigma, Dual specificity mitogen-activated protein kinase kinase 1, GST26/CRAF chimera, ... Authors: Quade, B, Cohen, S.E, Huang, X. Deposit date: 2024-03-06 Release date: 2024-04-17 Last modified: 2024-11-06 Method: ELECTRON MICROSCOPY (4.36 Å) Cite: The Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and RAF-Driven Cancers. Cancer Discov, 14, 2024