SRP68

This gene encodes a subunit of the signal recognition particle (SRP). The SRP is a ribonucleoprotein complex that transports secreted and membrane proteins to the endoplasmic reticulum for processing. The complex includes a 7S RNA and six protein subunits. The encoded protein is the 68kDa component of the SRP, and forms a heterodimer with the 72kDa subunit that is required for SRP function. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and three pseudogenes of this gene are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, May 2012]

本基因编码信号识别粒子（SRP）的亚基。SRP是一种核糖核蛋白复合体，负责将分泌蛋白和膜蛋白运输至内质网进行加工。该复合体包含7S RNA和六个蛋白亚基。编码的蛋白为SRP的68kDa组分，并与72kDa亚基形成异源二聚体，后者对于SRP的功能至关重要。对于此基因，已观察到存在多个剪接转录本变体，编码多种异构体，且该基因的三个假基因定位在17号染色体上Smith-Magenis综合征区域。[由RefSeq提供，2012年5月]