The molecular architecture of the desmosomal outer dense plaque by integrative structural modeling

This record pertains to the integrative model of the desmosome ODP based on data from X-ray crystallography, electron cryo-tomography, immuno-electron microscopy, yeast two-hybrid experiments, co-immunoprecipitation, in vitro overlay, in vivo co-localization assays, in-silico sequence-based predictions of transmembrane and disordered regions, homology modeling, and stereochemistry information. The modeling was performed using Bayesian integrative structure determination via IMP (Integrative Modeling Platform).

This record contains a) compressed version of Github folder: input data, scripts for modeling and results including bead models and localization probability density maps,and b) the ensemble of major cluster models for the main and supplementary runs reported in the paper.