To study the mechanism of resistance to ivosidenib, we developed a model of acquired drug resistance by treating ivosidenib-sensitive OCI-mIDH1/N cells continuously with ivosidenib in culture for a pe

NIAID Data Ecosystem40

Gene expression of A204 parental and acquired resistant cells treated with Pazopanib, Dasatinib, and Sunitinib.. Homo sapiens

化疗耐药机制

恶性横纹肌肿瘤

Malignant rhadboid tumours (MRTs) are lethal paediatric cancers characterised by a deficiency in the SWI/SNF subunit SMARCB1. Here we employ an integrated molecular profiling and chemical biology appr

NIAID Data Ecosystem20

RNA-seq analysis of vorinostat-resistant HCT116 cells following gene knockdown of potential vorinostat-resistance candidate genes. Homo sapiens

化疗耐药机制

转录组学分析

Potential vorinostat-resistance candidate genes were identified using RNA interference screening in vorinostat-resistant HCT116 cells (HCT116-VR) using a synthetic lethal approach. In order to underst

NIAID Data Ecosystem50

Additional file 3 of Adipocyte pyroptosis occurs in omental tumor microenvironment and is associated with chemoresistance of ovarian cancer

肿瘤微环境

化疗耐药机制

Additional file 3.

NIAID Data Ecosystem30