Serum microRNA profiles and functional enrichment analysis in comorbidity between Arnold-Chiari and Tourette syndromes: insights into their related pathological pathways

To identify the differential expression of serum microRNA as molecular fingerprints for Arnold-Chiari (AC) and Tourette syndromes (TS), also in comorbid status between both disorders (ACTS). To investigate on differentially expressed miRNA associations with the neuropsychological and neuroimaging parameters for each participant and their potential involvement in AC and TS pathological pathways. This study profiled the miRNA expression in sera of 10 AC patients, 11 ACTS patients, 6 TS patients and 8 unaffected controls (NC)