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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells. Bertolin et al.

NIAID Data Ecosystem2026-05-02 收录

DNA复制叉稳定性

细胞DNA损伤修复

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资源简介：

Raw data for Bertolin et al. MOLECULAR-CELL-D-24-01947

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创建时间：

2025-07-21

DNA复制叉稳定性

组蛋白泛素化

Aiming at better understanding the role of non-canonical ubiquitin-mediated events in the control of DNA replication, we made quite relevant observations on the role of key DNA damage response factors

NIAID Data Ecosystem80

Dynamics of de novo heterochromatin assembly and disassembly at replication forks ensures fork stability

DNA复制叉稳定性

组蛋白修饰

Analysis of histone PTM levels in proliferating, quiescent and HU-treated TIG3 fibroblasts. TIG3 fibroblasts were cultured in the absence or presence of HU (600 μM) for at least 6 days, rendering cell

NIAID Data Ecosystem50

U2OS Cell Cycle Transition Curve-- NCS 100 ng/mL

细胞DNA损伤修复

活细胞延时成像

U2OS cells expressing the PCNA-mCherry reporter were induced with 100 ng/mL NCS at 20.4 hours into the movie and then imaged for another 48 hours. Time-lapse images were taken every 20 minutes.

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RPE-1 Cell Cycle Transition Curve - NCS 25 ng/mL-3

细胞DNA损伤修复

延时活细胞成像

RPE-1 hTERT cells expressing the PCNA-mCherry reporter were induced with 25 ng/mL NCS 15.3 hours into the movie and then imaged for another 48 hours. Time-lapse images were taken every 10 minutes. Thi

NIAID Data Ecosystem60

Rad53 checkpoint kinase couples leading and lagging strand DNA synthesis

DNA复制叉稳定性

复制检查点调控机制

In response to DNA replication stress, DNA replication checkpoint is activated to maintain fork stability, a process critical for maintenance of genome stability. However, how DNA replication checkpoi

NIAID Data Ecosystem50

The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells. Bertolin et al.

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