Drug development requires significant time and financial resources. Despite the remarkable success in treating patients infected with the human immunodeficiency virus (HIV), which causes serious infec
BackgroundSystematic reviews of treatment interventions in stable or chronic conditions often require the synthesis of clinical trials with a cross-over design. Previous work has indicated that method
Background: Randomized control trials (RCTs) are considered the highest level of evidence for therapeutic research. Surgical RCTs, however, have drawbacks, leading some to question their role in filli
