tRFs/tiRNAs expression signature of low-glucose-treated HPAF-II cells

Glucose metabolism makes contributions to the development of pancreatic ductal adenocarcinoma (PDAC). Meanwhile, tsRNAs, including tRNA-derived fragment (tRF) and tRNA-derived stress-induced RNA (tiRNA), a subset of noncoding RNAs, exerts a vital role in glucose metabolism and cancer development. Analysis of high-glucose-treated and none glucose-treated HPAF-II cells from 6 samples (3 samples each group) was conducted. Results indicate insight into molecular signature of the pathogenesis of PDAC in abberant glucose metabolism. High throughput sequencing analysis was carried out to identify the differentially expressed tRFs/tiRNAs between high-glucose-treated and none glucose-treated HPAF-II cells (3 samples each group).