High-resolution H&E images for Visium spatial transcriptomics samples in GSE273378 — Steiner et al., Nature Communications

High-resolution H&E whole-slide images for Visium spatial transcriptomics samples (GSE273378) — Steiner et al., Nature Communications Creators: Lenburg, Marc — Boston University Chobanian & Avedisian School of Medicine Beane-Ebel, Jennifer — Boston University Chobanian & Avedisian School of Medicine Steiner, Dylan — Boston University Chobanian & Avedisian School of Medicine Burks, Eric — Boston Medical Center (Confirm ORCID iDs if you want them attached — not required to publish.) Description: This dataset contains high-resolution (whole-slide, ~400x) H&E-stained histology images corresponding to the 10x Genomics Visium spatial transcriptomics samples deposited under GEO accession GSE273378, which accompanies: Steiner D, et al. "Vascular invasion-associated gene expression is detectable in pre-surgical biopsies of stage I lung adenocarcinoma." Nature Communications (2026). DOI: 10.1038/s41467-026-70600-2. PMID: 41876493. The GEO submission includes Visium count matrices and lower-resolution histology images embedded in the standard Space Ranger output; it does not include the original whole-slide TIFF files. This archive provides those original files for users (e.g., those training image models on paired histology/spatial-transcriptomics data) who need full-resolution imagery. File-to-sample mapping (also provided as HE_image_GSM_mapping.csv in this record): Filename Slide_ID Sample_ID GSM_ID V10N16-321_A1.tif SNV10N16-321-A LM_SD_5 GSM8427434 V10N16-321_B1.tif SNV10N16-321-B LM_SD_6 GSM8427435 V10N16-321_C1.tif SNV10N16-321-C LM_SD_7 GSM8427436 V10N16-321_D1_flipped.tif SNV10N16-321-D LM_SD_1216_8 GSM8427437 V10N16-322_A1_flipped.tif SNV10N16-322-A LM_SD_1216_1 GSM8427428 V10N16-322_B1.tif SNV10N16-322-B LM_SD_2 GSM8427431 V10N16-322_C1.tif SNV10N16-322-C LM_SD_3 GSM8427432 V10N16-322_D1.tif SNV10N16-322-D LM_SD_4 GSM8427433 V10N16-323_A1.tif SNV10N16-323-A LM_SD_9 GSM8427438 V10N16-323_B1.tif SNV10N16-323-B LM_SD_10 GSM8427439 V10N16-323_C1.tif SNV10N16-323-C LM_SD_11 GSM8427430 V10N16-323_D1.tif SNV10N16-323-D LM_SD_1216_12 GSM8427440 V10N16-324_A1.tif SNV10N16-324-A LM_SD_13 GSM8427441 V10N16-324_B1.tif SNV10N16-324-B LM_SD_1216_14 GSM8427442 V10N16-324_C1.tif SNV10N16-324-C LM_SD_15 GSM8427443 V10N16-324_D1.tif SNV10N16-324-D LM_SD_16 GSM8427429 Analysis code for this study is available at: https://github.com/dst53/Steiner_NatComm/tree/v1.0.0