Comparison of cerebrospinal fluid proteomics between Demyelinating disease and non-inflammatory neurological controls

Demyelinating disease is a disease of the nervous system in which the nerve demyelinating is the main or primary lesion, and the axon, cell body and glia are relatively lightly damaged. It can occur in the central nervous system or the peripheral nervous system. The demyelinating diseases of central nervous system are represented by multiple sclerosis (MS) and neuromyelitis optica (NMO) while Guillain-Barre Syndrome (GBS) is a demyelinating disease of the peripheral nervous system. We aimed to identify the key proteins in demyelinating disease and describe the proteomic pattern of MS, GBS and NMO. This study used high-resolution liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), in combination with quantitative 10-plex tandem mass tag labeling, to profile protein changes in MS, GBS and NMO.