A Hemostatic Nanocomposite for Targeted Endovascular Sealing of Cerebral Vessel Ruptures Without Inducing Thrombosis

Intracranial hemorrhage (ICH) remains a leading cause of mortality and disability worldwide, with current hemostatic interventions often triggering iatrogenic thrombosis or failing to restore vascular integrity. Here, we propose a novel bioinspired nanocomposite material—NeuroSeal-X—engineered to selectively adhere to exposed subendothelial collagen at rupture sites, polymerize in situ under physiological conditions, and mechanically reinforce vessel walls without activating platelets or the coagulation cascade. We present a multi-scale modeling framework integrating patient-specific hemodynamics, Bayesian uncertainty quantification, and in silico validation. Our simulations demonstrate >92% sealing efficacy under pulsatile flow (Re = 400–800) with no evidence of thrombus formation across 10,000 Monte Carlo simulations. The material’s predicted biodegradability, non-immunogenicity, and endothelial regenerative capacity are supported through mechanistic biomolecular analysis and literature extrapolation. Code, data, and full derivations are provided for full reproducibility.