Effects of various xanomeline treatment conditions on the specific binding of [3H]NMS or [3H]QNB in CHO hM1 cells.

Data shown in Fig. 4 were corrected for protein as indicated in results. Parameters derived from nonlinear regression analysis are shown as mean ± S.E.M. of three to four experiments conducted in triplicate. All other details as in Table 1.aControl, naïve cells were incubated simultaneously with xanomeline and the radioligands.*Significant difference (p50 between the indicated groups and control as determined by one-way ANOVA followed by Dunnett’s post-test.