Ancestry-specific regulatory and disease architectures are likely due to cell-type-specific gene-by-environment interactions

This repository contains raw data, preprocessing scripts, and analysis code to replicate S-LDXR analysis from Wang et al. The project directory is organized as follows: - `DEstats.tgz`: Differential gene expression statistics between EAS and EUR for each 7 main cell types. - `Lupus_study_adjusted_compressed.h5ad.gz`: The single-cell dataset of Perez*, Gordon*, Subramaniam* et al. 2022 Science used in this study. - `sldxr_annotations.tgz`: Main S-LDXR annotations used in this study. - `sldxr_ref_files.tgz`: S-LDXR reference files (baseline-LD-X annotations, regression weights and EAS and EUR 1000G genotype reference files) - `README.sh`: This README file.- `sumstats.tgz`: GWAS summary statistics of 31 traits in EAS and EUR populations.