Delivery of a tissue derived extracellular matrix gel improves recovery following both acute and chronic disuse muscle injuries.

To evaluate decellularized skeletal muscle extracellular matrix hydrogel effectiveness in treating disuse atrophy using a mouse hindlimb suspension (HU) model. Male C57BL/6J mice were subjected to 5 days of hind limb unloading then received intramuscular matrix gel on the left TA. We then performed gene expression profiling analysis using data obtained from RNA-seq from mouse TA muscles (n=4 for matrix gel treatment, n=4 for PBS control , and n=4 for uninjured control) at day 7 post matrix gel injection Comparative gene expression profiling analysis of RNA-seq data from mouse Tibialis anterior muscle tissues between uninjured, Pbs and gel treatment