<b>Supporting data for manuscript</b> "<b>Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins</b>"

The CSV file 'Eyreetal_DrainingVein_SourceData' contains the averaged time series traces and extracted metrics from individual experiments used across Figures 1-5 in the manuscript "Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins". The following acronyms included in the CSV file are defined as follows: Hbt is total hemoglobin, Art is artery region, DV is draining vein region, WV is whisker vein region, SEM is standard error mean, TS is time series, max peak is maximum peak, min peak is minima, AUC is area under the curve, WT is wild-type, AD is Alzheimer's disease, ATH is atherosclerosis and MIX is mixed AD/atherosclerosis. The locomotion values (traces and metrics) are in arbitrary units with larger integers representing a greater displacement of the spherical treadmill, the hemodynamic (Hbt) values (traces and metrics) are a percentage change from the normalised baseline (prior to stimulus presentation), and the corresponding time series vector is presented in seconds. The MATLAB file 'dvpaper_tstraces.mat' contains the individual hemodynamic traces (total hemoglobin, Hbt; oxygenated hemoglobin, HbO; deoxygenated hemoglobin, Hbr) across all included locomotion events (N=2343) for the artery (art), whisker vein (wv), and draining vein (dv) regions, which the corresponding locomotion traces (walk_tot_interp), time series (time_haem, seconds). The MATLAB file 'dvpaper_tstraces_meningeal.mat' contains the individual hemodynamic traces across all included locomotion events (N=1224) where a meningeal vessel was detectable in the thin cranial window. These time series traces are 2-dimensional with dimension 1 (rows) representing the individual locomotion events which the data has been cut around, and dimension 2 (length) representing the number of frames captured (200 frames, recording speed 7.9932 frames per second). The trace parameters for the locomotion, artery, whisker vein, draining vein, meningeal vein (mn) traces are contained inside the 'traceparameters' variables and contain the maximum peak, time to maximum peak, minima, time to minima, and area under the curve for the corresponding time series traces. The following labelling information is also included in the file: animal ID, group ID (i.e. 2=WT, 1=AD, 3=ATH or MIX), sex (1=male, 2=female), session ID (corresponding to the experimental imaging day), and trial ID (corresponding to the order of detected locomotion events within each experimental imaging session). The CSV files 'drainingVein_data4R' and 'drainingVein_topBottomLocoGrps_data4R' contain the time series metrics (including maximum peak, minima etc) with corresponding labels (including animal ID, sex, session ID, etc) present in the MATLAB file extracted into spreadsheets for loading into RStudio to conduct statistical analyses using linear mixed models. <br>

CSV文件`Eyreetal_DrainingVein_SourceData`收录了论文《Voluntary locomotion induces an early and remote hemodynamic decrease in the large cerebral veins》中图1至图5所用到的各项独立实验的平均时间序列轨迹与提取得到的实验指标。该CSV文件中出现的缩写定义如下：Hbt（total hemoglobin，总血红蛋白）；Art（artery region，动脉区域）；DV（draining vein region，引流静脉区域）；WV（whisker vein region，触须静脉区域）；SEM（standard error mean，标准误）；TS（time series，时间序列）；max peak指峰值最大值；min peak指谷值最小值；AUC（area under the curve，曲线下面积）；WT（wild-type，野生型）；AD（Alzheimer's disease，阿尔茨海默病）；ATH（atherosclerosis，动脉粥样硬化）；MIX（mixed AD/atherosclerosis，阿尔茨海默病/动脉粥样硬化混合型）。运动相关数值（轨迹与指标）以任意单位表示，数值越大代表球形跑步机的位移幅度越高；血流动力学相关（Hbt）数值为归一化基线（刺激呈现前）的百分比变化量，对应的时间序列向量以秒为单位。MATLAB文件`dvpaper_tstraces.mat`收录了所有纳入的运动事件（N=2343）中，动脉（art）、触须静脉（wv）、引流静脉（dv）区域的独立血流动力学轨迹（总血红蛋白Hbt、氧合血红蛋白HbO、脱氧血红蛋白Hbr），同时配套提供对应的运动轨迹（walk_tot_interp）与时间序列（time_haem，单位：秒）。MATLAB文件`dvpaper_tstraces_meningeal.mat`收录了所有纳入的、可在薄颅骨窗中检测到脑膜血管的运动事件（N=1224）中的独立血流动力学轨迹。此类时间序列轨迹为二维结构：第1维度（行）代表围绕其截取数据的单个运动事件，第2维度（长度）代表捕获的总帧数（共200帧，录制帧率为7.9932帧/秒）。运动、动脉、触须静脉、引流静脉、脑膜静脉（mn）轨迹的特征参数均存储于traceparameters变量中，包含对应时间序列轨迹的峰值最大值、峰值到达时间、谷值最小值、谷值到达时间以及曲线下面积。该文件还包含以下标注元数据：动物ID、组别ID（即2=野生型WT，1=阿尔茨海默病AD，3=动脉粥样硬化ATH或混合型MIX）、性别（1=雄性，2=雌性）、实验会话ID（对应实验成像日期）、试次ID（对应每个实验成像会话中检测到的运动事件的排列顺序）。CSV文件`drainingVein_data4R`与`drainingVein_topBottomLocoGrps_data4R`收录了时间序列指标（包括峰值最大值、谷值最小值等），并附带对应的标注信息（包括动物ID、性别、会话ID等）。此类数据已从MATLAB文件中提取为电子表格格式，可加载至RStudio中以线性混合模型开展统计分析。

搜集汇总

背景与挑战

背景概述

该数据集为研究论文《自愿运动诱导大静脉早期远程血流动力学降低》提供支持数据，包含CSV和MATLAB文件，涵盖动物实验中的血流动力学时间序列、运动轨迹和提取指标，用于分析不同脑区血管在自愿运动期间的响应。数据集包括多个实验组（如野生型、阿尔茨海默病模型）的数据，并附有详细标签和方法说明，适用于统计分析和神经科学研究。