Hippocampus-specific loss of intellectual disability-related gene Brpf1 impaired spatial and contextual learning

To help explain the dominant symptom-intellectual disability found in those patients with BRPF1 mutations, we used a genetically modified mouse model and used several methods to study the effect caused by BRPF1 knockout. We then performed gene expression profiling analysis using data obtained from RNA-seq of two genotypes of mice. Comparative gene expression profiling analysis of RNA-seq data for WT mice and cKO mice为阐释BRPF1突变患者所呈现的主导症状——智力障碍，我们采用基因修饰小鼠模型，通过多种手段探究BRPF1基因敲除所产生的影响。随后，我们基于两种基因型小鼠的RNA测序（RNA-seq）数据开展基因表达谱分析，并针对野生型（WT）小鼠与条件性敲除（cKO）小鼠的RNA测序数据进行对比基因表达谱分析。