Tetrahydro-1,3-oxazepines via Intramolecular Amination of Cyclopropylmethyl Cation
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https://figshare.com/articles/dataset/Tetrahydro_1_3_oxazepines_via_Intramolecular_Amination_of_Cyclopropylmethyl_Cation/2156797
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资源简介：
An efficient synthesis of tetrahydro-1,3-oxazepines
was developed
involving the regioselective intramolecular amination of cyclopropylmethyl
cation. The cation was generated by the abstraction of one imidate
group in bis-imidate bearing a carbocation-stabilizing substituent.
Using 1,1,2,3-tetrasubstituted cyclopropane substrates, highly diastereoselective
intramolecular amination to trans-tetrahydro-1,3-oxazepines
was achieved. The resulting tetrahydro-1,3-oxazepines were transformed
to the homoallylamine derivatives in high yields.
创建时间：
2016-02-13
