Binary outcome: Simulation results given the minor allele frequency (MAF) = 0.5.

Means and standard errors of estimated coefficients for different paths, indirect effects (IEs) and proportions of the total effect mediated (PMs); and coverage probabilities of the 95% confidence intervals for the estimations of IE and PM, obtained based on 500 replicates, each with 500 cases and 500 controls, given the minor allele frequency (MAF) = 0.5. Different scenarios were considered based on different values of a, b0, b, censoring percentage (CP), and disease prevalence (prev), with a0 = 6 and . (XLSX)