Variation in PC model’s somatic ionic charge density vs. field intensity.

The table reports the absolute difference (Δc) between the charge density estimated for ionic currents measured at the soma of the PC model under constant electric fields (EF) of intensity -1.5 V/m and +1.5 V/m, respectively. Charge density of an ionic current is measured at the soma during the silent period. Ionic currents include leakage currents (leakage) and currents flowing through sodium (Na+) Nav1.6 channels, hyperpolarization activated cyclic nucleotide-gated cationic (HCN) channels, potassium (K+) channels (combination of Kv1.1, Kv1.5, Kv3.3, Kv3.4, Kv4.3, KCa1.1, KCa 2.2, KCa 3.1, and Kir2 channels), and calcium (Ca2+) channels (i.e., combination of Cav3.1, Cav 3.2, Cav 3.3, and Cav2.1 channels). See [34] for a definition of the ionic channel mechanisms. Since the duration, Tsp, of the silent period changes with the EF intensity, the charge density was computed as the integral of the ionic current density from the end of the complex spike till the end of the shortest Tsp, i.e., 251 ms. (XLSX)