IL-2 mediates CD4 help for memory-like Clone 4 CD8⁺ T cells in the induction of autoimmune diabetes.

aPurified transgenic CD8+ and CD4+ T cells were injected as indicated into irradiated InsHA mice, 24 h after irradiation. bMice were treated either with MR1 anti-CD40L mAb or S4B6+JES6-1 anti-IL-2 mAbs or with their respective isotype matched antibodies. cThe onset of autoimmunity was evaluated by measuring blood glucose levels. Mice were followed over a 21 day period and were considered diabetic when levels were above 300 mg/dl in two consecutive measurements. The day of disease onset (d) is indicated.