Chronic alcohol metabolism results in DNA repair infidelity and cell-cycle-induced senescence in neurons

Chronic and excessive binge-like drinking is a risk factor to pathological cognitive decline and dementia, but the mechanism underlying the prolonged and lasting effect of alcohol even in abstainers remains elusive. This study investigates how ethyl alcohol directly results in metabolic reprograming and persistent physiological changes in brain cells that underlies such effect. Overall design: RNA sequencing of brain cortex samples from wildtype mice subjected to a binge-like drinking paradigm or vehicle control.