Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers

NIAID Data Ecosystem2026-03-11 收录

乳腺癌遗传

BRCA2基因

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32259 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2019-11-08

Genome-wide mapping of DNA-methylation in hTert-HME1 cell line treated with control or BRCA2 siRNAs and grown with or without EGF (epithelial growth factor). Genome-wide mapping of DNA-methylation in hTert-HME1 cell line treated with control or BRCA2 siRNAs and grown with or without EGF (epithelial growth factor)

BRCA2基因

肿瘤抑制基因

Individuals with a single functional copy of the BRCA2 tumor suppressor have elevated risks for breast, ovarian, and other solid tumor malignancies. The exact mechanisms of carcinogenesis due to BRCA2

NIAID Data Ecosystem50

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories. Homo sapiens

前列腺癌分子机制

BRCA2基因

Germline mutations in the BRCA2 tumour suppressor are associated with both an increased lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. To understand this a

NIAID Data Ecosystem30

Logistic regression analyses on associations among rs2046210, rs4784227 and risk of breast cancer.

乳腺癌遗传

基因变异关联分析

aReference allele/risk allele. bAdjusted by age, BMI, age at menarche, age at first live birth, menopausal status and family history of breast cancer where appropriate. cP trend for genotypes between

NIAID Data Ecosystem30

DataSheet1_Association Between the TP53 Polymorphisms and Breast Cancer Risk: An Updated Meta-Analysis.PDF

乳腺癌遗传

基因多态性分析

Background: The relationship of TP53 codons 72, IVS3 16 bp, and IVS6+62A > G polymorphisms with breast cancer (BC) risk has been analyzed in seventeen published meta-analyses. However, the credibility

NIAID Data Ecosystem40

MED12L Gene Alterations Define Aggressive BRCA2-Mutant Prostate Cancers

前列腺癌基因组

BRCA2基因

Germline mutation of BRCA2 increases the lifetime risk of developing prostate cancer (PCa) by over 700%. BRCA2-mutant PCa have poorer prognosis than sporadic PCa, with rapid development of metastatic,

NIAID Data Ecosystem30

Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers

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