Perturbation of Ca²⁺ homeostasis by compounds clustered with apogossypol.

Listing of the eleven compounds that clustered with apogossypol in Figure 1 and their pharmacological activities. HeLa cells after 4 h exposure to ivermectin (20 µM), clotrimazole (50 µM), niclosamide (50 µM), pyrvinium (20 µM), dequalinium (10 µM), gossypol (10 µM), valinomycin (20 µM), thapsigargin (10 µM), chlorpromazine (20 µM), trifluoperazine (20 µM) or NDGA (50 µM) exhibited varying levels of ER membrane reorganization, from minimal (+) to extensive reorganization (+++). Ten of the eleven compounds have been described to perturb cellular Ca2+ homeostasis by different mechanisms.