Independent associations between blood lipid profiles and lung cancer risk

In our study analyzed 1593 newly diagnosed lung cancer patients and matched healthy controls to explore both linear and non-linear connections between blood lipid profiles and lung cancer risk. Our findings indicate that lung cancer patients typically exhibit lower levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Notably, we found that hyper-TC and low-HDL-C are correlated with an increased risk of lung cancer, with non-linear relationships identified between TC/HDL-C and lung cancer risk.Additionally, our multiple linear regression analysis revealed that triglycerides are associated with squamous cell carcinoma antigen (SCC), and HDL-C is linked with neuron-specific enolase (NSE), cytokeratin 19 fragments (CYFRA21-1), SCC, and tumor-associated antigen 125 (CA-125). Our findings emphasize the potential role of lipid levels in the pathology of lung cancer, offering new insights for future prevention and treatment strategies.