Microbiome alterations driven by Trypanosoma cruzi infection in two disjunctive murine models

Alterations caused by Trypanosoma cruzi in the gut microbiome composition may play a key role in the host-parasite interactions and may be involved in a decrease of bacterial taxa and metabolic pathways that could be related to changes in physiology and immune responses against the parasite, promoting the establishment and progression of the infection. Therefore, we implemented a murine model with two mouse strains, BALBc and BL6, to evaluate the impact of Trypanosoma cruzi (Tulahuen strain) infection on the gut microbiome using shotgun metagenomics.