Information S1 - Graft versus Host Disease in the Bone Marrow, Liver and Thymus Humanized Mouse Model

Table 1, Figures 1–3. Table 1: P values and relative risk for the influence of HLA class I alleles on GVH incidence. Relative risk and significance for various HLA class I alleles was calculated in Figure 2. Displayed are the relative risk values, 95% confidence intervals, and P values for each HLA allele. Figure 1. Further histologic characterization of GVH occurring in humanized BLT mice. (A–D)Tissues from humanized BLT mice with clinical GVH as in Figure 1 were harvested for histologic analysis. Figure 2. Cellular and molecular characterization of GVH in BLT mice. Splenocytes were isolated and stimulated as in Figure 3E, and the resulting supernatant was analyzed for levels of IL10. Figure 3: Replicate Data for Dermal Macrophage Expression Profile. Macrophages were isolated as in Figure 4, RNA extracted, and expression of the indicated genes measured by realtime PCR. Shown are independent experimental replicates of the data provided in Figure 4B. (PDF)