The neuronal GclC overexpression in Drosophila melanogaster reverses aging-related transcriptomic changes in thorax

It is known from the transcriptomic studies that the effects of aging are tissue specific. It has shown that the neuronal Gclc overexpression in D. melanogaster increased lifespan and improved certain physiological parameters associated with health benefits (locomotor activity, circadian rhythmicity and stress resistance).Sarcopenia is aging-related life-threatened condition and its mechanisms are important for future prevention and treatment. The purpose of the present study was to investigate the effects of the neuronal GclC overexpression on gene expression levels in imago thorax, which is primarily composed of muscles.