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A geographic history of human genetic ancestry

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DataONE2025-03-10 更新2025-04-26 收录
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Describing the distribution of genetic variation across individuals is a fundamental goal of population genetics. We present a method that capitalizes on the rich genealogical information encoded in genomic tree sequences to infer the geographic locations of the shared ancestors of a sample of sequenced individuals. We use this method to infer the geographic history of genetic ancestry of a set of human genomes sampled from Europe, Asia, and Africa, accurately recovering major population movements on those continents. Our findings demonstrate the importance of defining the spatial-temporal context of genetic ancestry to describing human genetic variation and caution against the oversimplified interpretations of genetic data prevalent in contemporary discussions of race and ancestry., , , # A geographic history of human genetic ancestry [https://doi.org/10.5061/dryad.p5hqbzkwz](https://doi.org/10.5061/dryad.p5hqbzkwz) ## Description of the data and file structure Data and codes for testing and fitting GAIA ### Files and variables #### File: data.tar.gz **Description:** A gzip compressed archive with the following contents: The `slim` directory contains simulation scripts and outputs for testing GAIA with the SLiM software in continuous and discrete geographic space. Each subdirectory corresponds to a different geographic space representation. The following subdirectories and files include: * `continuous-space/` : Simulations on an abstract continuous plane * `uniform-landscape/` : SLiM simulations with spatially homogeneous carrying capacity * `gaussian-dispersal/` : simulations with a Gaussian dispersal kernel * `analysis/` * `performance.R, performance.sh` : R script and shell script used to run GAIA on each of the simulation tree sequences ...,
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2025-03-13
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