Additional file 1 of Cathepsin H increases the risk of diabetic retinopathy: evidence from Mendelian randomization and bioinformatic analysis

Supplementary Material 1: Supplementary data 1. Leave-one-out analysis between cathepsins and different diabetic chronic complications. Supplementary Table 1. Characteristics of SNPs serving as instrumental variables. Supplementary Table 2. The results of bidirectional MR analysis between six cathepsins and the risk of nine diabetic chronic complications. Supplementary Table 3. Multivariable MR analysis of cathepsins and different diabetic chronic complications. Supplementary Table 4. The results of cis-eQTL MR and SMR analysis. Supplementary Table 5. 577 differentially expressed genes identified from GSE94019 based on the median expression expression of Cathepsin H. Supplementary Table 6. The causal effects of immunophenotypes on DR, PDR, and diabetic maculopathy, and the causal effects of Cathepsin H on immunophenotypes associated with DR, PDR, or diabetic maculopathy.