Synthesis of an Ethynyl Carbamate and Application for Enantioselective Cyclocarbolithiation
收藏NIAID Data Ecosystem2026-03-06 收录
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资源简介：
The intramolecular trans-cyclocarbolithiation of the α-lithiated 4-substituted 5-hexynyl carbamate (1S,4RS)-14 employing lithiodestannylation is presented. The 5-exo-dig cyclization products cis-/trans-16a were formed exclusively. The highly enantioenriched organotin precursor (S)-11 was synthesized via an asymmetric deprotonation of the corresponding alkyl carbamate 10 by the chiral complex sec-butyllithium/(−)-sparteine and subsequent substitution with tributyltin chloride.
创建时间：
2016-08-20
