Activated NTRK2 signals through RAS

Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream RAS signaling. The best studied mechanism for activation of RAS signaling downstream of NTRK2 is through SHC1-mediated recruitment of the GRB2:SOS1 complex, triggering SOS1-mediated guanine nucleotide exchange on RAS and formation of active RAS:GTP complexes (Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999).

神经营养因子受体NTRK2（TRKB）被脑源性神经营养因子（BDNF）或NTF4激活，进而触发了下游的RAS信号通路。在NTRK2下游RAS信号通路激活的研究中，最为深入的机制是通过SHC1介导的GRB2:SOS1复合物的募集，引发SOS1介导的RAS上鸟苷酸交换，并形成活性RAS:GTP复合物（Minichiello等人，1998年；McCarthy和Feinstein，1999年；Yuen和Mobley，1999年）。