Bifidobacterium longum R0175 Protects Rats From D- Galactosamine-Induced Acute Liver Failure. rat gut metagenome

Background: Acute liver failure is a severe liver disorder and poses a huge global challenge. Researches have shown that probiotics may improve acute liver injury. Previous studies regarding Bifidobacterium longum R0175 mainly focused on its psychic function. The current research focused on the protective efficacy of B. longum R0175 on acute liver failure caused by D-Galactosamine (GalN) in rats and further tested the hypothesis that B. longum R0175 achieved its central effects of liver protection through intestinal microbiota, fecal metabolites, and inflammation inhibiting.Results: We found that oral gavage of B. longum R0175 remarkably reduced the severity of liver injury in D-GalN-treated rats, evidenced by decreased serum levels of AST and TBAs (PDiscussion: Overall, our results illustrated that B.longum R0175 exhibited protective effects on rats with acute liver failure and it has greater clinical application prospects to be explored.