Acquired resistance to BRAF-inhibitors restores melanoma tumor immune suppression. Mus musculus
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The acquisition of resistance to BRAF-inhibitors results in MAPK-driven, CCL2-mediated repopulation of intratumoral myeloid-derived suppressor cells (MDSCs) in a mouse model of melanoma, and the depletion of MDSCs allows for effective immunotherapy against drug-resistant tumors. Overall design: Gene expression and intrinsic subset assignment were measured in 16 mouse biopsies
创建时间：
2016-03-14
