Low-carbohydrate diet in children and young people with type 1 diabetes: a randomized controlled trial with cross-over design

We investigated whether a short period of tightly controlled low-carbohydrate diet (LCD) leads to higher time in range without increasing the associated risks in children and young people with diabetes (CYPwD). Thirty-five (CYPwD) were recruited into this randomized controlled cross-over study (20 female; 20 CSII; age 14.5 +/- 2.9 years; HbA1c 48.9 +/- 9.4 mol/mol). The interventions were five and five weeks of readymade food box deliveries of isocaloric diets in random order: either LCD (94.5 +/- 4.7 g/day) or recommended carbohydrate diet (RCD) (191 +/- 19.2 g/day). The outcomes were continuous glucose monitoring parameters, anthropometric, laboratory and quality of life (QoL) data.This project characterises the reaction of the bacteriome to the controlled diets.