Association between preoperative medication lists and postoperative hospital length of stay after endoscopic transsphenoidal pituitary surgery

Background: Endoscopic transsphenoidal surgery is the most common technique for resection of pituitary adenoma. Data on factors associated with extended hospital stay after this surgery are limited. We aimed to characterize the relationship between preoperative medications and the risk of prolonged postoperative length of stay after this procedure.
Methods: This single-center, retrospective cohort study included all adult patients scheduled for transsphenoidal pituitary surgery from July 1st, 2016 to December 31st, 2019. Anatomical Therapeutic Chemical codes were used to identify patients’ preoperative medications. The primary outcome was prolonged postoperative hospital length of stay. Secondary outcomes included unplanned admission to the Intensive Care Unit, in-hospital and one-year mortality. We developed a descriptive logistic model that included preoperative medications, obesity, and age.
Results: Median postoperative length of stay was 3 days for the 704 analyzed patients. A prol...