Pharmacokinetic parameters of rifabutin and 25-O desacetyl rifabutin.

Data are presented as medians with the range in parenthesisOD – once daily; TPW - three times per week; Cmax -peak concentration; Tmax - time to reach peak concentration; C0 - concentration at time 0; Cmin -concentration at the end of a dosing interval (24 h or 48 h);NA non available, Cmin 48 h post dosing non available in 10 patients; AUCτ – area under the curve during a dosing interval τ, τ is 24 h for OD dosing and 48 h for TPW. Cave – average concentration (AUCτ/τ).