Mediation tests for adiponectin levels on the association between CDH13 genotypes and metabolic phenotypes.

CDH13 genotypes represent rs12051272, which was analyzed in the dominant models, α: unstandardized coefficient for the association between the CDH13 genetic variants and log adiponectin levels; β: unstandardized coefficient for the association between adiponectin and metabolic phenotypes, such as diastolic BP, glucose levels, QUICKI, HDL cholesterol, triglyceride levels and metabolic syndrome (when adjusted for the CDH13 genetic variants). Direct effect = γ’, Total effect = αβ + γ’, Mediation (indirect) effect = αβBP, blood pressure; HDL, high-density lipoprotein; QUICKI, quantitative insulin sensitivity check index;Mediation tests for adiponectin levels on the association between CDH13 genotypes and metabolic phenotypes.