Top canonical pathways in THP-1 cells after 8 h treatment with 10% CSE.

THP-1 cells were treated for 8 hours with RPMI-1640 control medium (n = 6) or 10% CSE-conditioned medium (n = 6). Genes that were significantly modified by ≥1.5-fold, as assessed using student's t-test followed by Benjamini-Hochberg FDR correction, were imported into Ingenuity Pathway Analysis software. The table shows the top 5 canonical pathways identified from genes differentially expressed by ≥1.5-fold in THP-1 cells treated with 10% CSE. The P-value for association of genes and the described canonical pathways, and the ratio of significantly differentially expressed pathway components compared to the total components in that pathway was generated using Fisher's exact test.