Structures and mechanisms of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis

NIAID Data Ecosystem2026-05-02 收录

寄生虫蛋白结构与功能

丝氨酸蛋白酶抑制剂

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Structures and mechanisms of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis

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2024-09-25

A bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

疟疾研究

丝氨酸蛋白酶抑制剂

Malaria causes worldwide morbidity and mortality, and while chemotherapy remains an excellent means of malaria control, drug-resistant parasites necessitate the discovery of new antimalarials. Peptida

Research Data Australia100

A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE

丝氨酸蛋白酶抑制剂

生物与药物结构设计

A NOVEL SERINE PROTEASE INHIBITION MOTIF INVOLVING A MULTI-CENTERED SHORT HYDROGEN BONDING NETWORK AT THE ACTIVE SITE Descriptor: 2-(2-HYDROXY-PHENYL)-3H-BENZOIMIDAZOLE-5-CARBOXAMIDINE, BETA-TRYPSIN,

Protein Data Bank Japan2024-10-30 更新50

PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS

丝氨酸蛋白酶抑制剂

结构药物发现

PREDICTION OF NOVEL SERINE PROTEASE INHIBITORS Descriptor: 2-PHENYLETHYLAMINE, CALCIUM ION, TRYPSIN Authors: Kurinov, I, Harrison, R.W. Deposit date: 1994-07-21 Release date: 1994-11-30 Last modified:

Protein Data Bank Japan2024-11-20 更新30

The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.

耐热蛋白质结构

丝氨酸蛋白酶抑制剂

Serpins fold into a native metastable state and utilize a complex conformational change to inhibit target proteases. An undesirable result of this conformational flexibility is that most inhibitory se

Research Data Australia100

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

丝氨酸蛋白酶抑制剂

蛋白质-配体相互作用

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors Descriptor: 3-{5-[AMINO(IMINIO)METHYL]-1H-BENZIMIDAZOL-2-YL}-1,1'-BIPHENYL-2-OLATE

Protein Data Bank Japan2024-10-30 更新40

Structures and mechanisms of serine protease inhibitors of Trichinella spiralis and Trichinella pseudospiralis

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